期刊
NUCLEIC ACIDS RESEARCH
卷 40, 期 4, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkr1124
关键词
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资金
- European Fund for Regional Development (FEDER) through the Operational Program Competitiveness Factors (COMPETE)
- Portuguese Foundation for Science and Technology (FCT) [FCOMP-01-0124-FEDER-010099, PTDC/EIA-EIA/103099/2008, FCOMP-01-0124-FEDER-022682, PEst-C/EEI/UI0127/2011]
- European Social Fund
- Portuguese Ministry of Education and Science
- Fundação para a Ciência e a Tecnologia [PTDC/EIA-EIA/103099/2008] Funding Source: FCT
Research in the genomic sciences is confronted with the volume of sequencing and resequencing data increasing at a higher pace than that of data storage and communication resources, shifting a significant part of research budgets from the sequencing component of a project to the computational one. Hence, being able to efficiently store sequencing and resequencing data is a problem of paramount importance. In this article, we describe GReEn (Genome Resequencing Encoding), a tool for compressing genome resequencing data using a reference genome sequence. It overcomes some drawbacks of the recently proposed tool GRS, namely, the possibility of compressing sequences that cannot be handled by GRS, faster running times and compression gains of over 100-fold for some sequences. This tool is freely available for non-commercial use at ftp://ftp.ieeta.pt/similar to ap/codecs/GReEn1.tar.gz.
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