期刊
NUCLEIC ACIDS RESEARCH
卷 39, 期 14, 页码 6086-6099出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkr194
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资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan
- Mitsubishi Kagaku Institute of Life Sciences (MITILS)
- Grants-in-Aid for Scientific Research [22390038] Funding Source: KAKEN
The transcription factor HIF-1 alpha (hypoxia inducible factor 1 alpha) has an essential role in the maintenance of oxygen homeostasis in metazoans. HIF-1 alpha expression and activity in the hypoxic response is regulated at the translation and post-translational levels. However, the mechanism and modulator of HIF-1 alpha translation during hypoxia is not fully understood. We found that HIF-1 alpha expression during hypoxia was upregulated by the microRNA 130 (miR-130) family. Levels of the miR-130 family are elevated under hypoxia, and their target is DDX6 mRNA, which is a component of the P-bodies. Furthermore, we found that a decrease of DDX6 expression by the miR-130 family enhanced the translation of HIF-1 alpha in an internal ribosome entry site element-dependent manner. These results reveal a new HIF-1 alpha translational mechanism and a role for P-bodies in hypoxic stress.
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