4.8 Article

WormBase 2012: more genomes, more data, new website

期刊

NUCLEIC ACIDS RESEARCH
卷 40, 期 D1, 页码 D735-D741

出版社

OXFORD UNIV PRESS
DOI: 10.1093/nar/gkr954

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资金

  1. US National Institutes of Health [P41 HG02223, P41-HG02223]
  2. US National Human Genome Research Institute [P41-HG02223]
  3. British Medical Research Council [G070119]
  4. NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U41HG002223, P41HG002223] Funding Source: NIH RePORTER
  5. Medical Research Council [G0701197] Funding Source: researchfish
  6. MRC [G0701197] Funding Source: UKRI

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Since its release in 2000, WormBase (http://www.wormbase.org) has grown from a small resource focusing on a single species and serving a dedicated research community, to one now spanning 15 species essential to the broader biomedical and agricultural research fields. To enhance the rate of curation, we have automated the identification of key data in the scientific literature and use similar methodology for data extraction. To ease access to the data, we are collaborating with journals to link entities in research publications to their report pages at WormBase. To facilitate discovery, we have added new views of the data, integrated large-scale datasets and expanded descriptions of models for human disease. Finally, we have introduced a dramatic overhaul of the WormBase website for public beta testing. Designed to balance complexity and usability, the new site is species-agnostic, highly customizable, and interactive. Casual users and developers alike will be able to leverage the public RESTful application programming interface (API) to generate custom data mining solutions and extensions to the site. We report on the growth of our database and on our work in keeping pace with the growing demand for data, efforts to anticipate the requirements of users and new collaborations with the larger science community.

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