期刊
NUCLEIC ACIDS RESEARCH
卷 39, 期 9, 页码 3879-3891出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkq1355
关键词
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资金
- Wellcome Trust [073980/Z/03/Z, WT083481]
- MRC [G0801738]
- BBSRC RASOR (Radical Solutions for Researching the proteome)
- Scottish Bioinformatics Research Network
- Caledonian Research Foundation
- Medical Research Council [G0801738, G0301131] Funding Source: researchfish
- MRC [G0801738, G0301131] Funding Source: UKRI
There are two main classes of small nucleolar RNAs (snoRNAs): the box C/D snoRNAs and the box H/ACA snoRNAs that function as guide RNAs to direct sequence-specific modification of rRNA precursors and other nucleolar RNA targets. A previous computational and biochemical analysis revealed a possible evolutionary relationship between miRNA precursors and some box H/ACA snoRNAs. Here, we investigate a similar evolutionary relationship between a subset of miRNA precursors and box C/D snoRNAs. Computational analyses identified 84 intronic miRNAs that are encoded within either box C/D snoRNAs, or in precursors showing similarity to box C/D snoRNAs. Predictions of the folded structures of these box C/D snoRNA-like miRNA precursors resemble the structures of known box C/D snoRNAs, with the boxes C and D often in close proximity in the folded molecule. All five box C/D snoRNA-like miRNA precursors tested (miR-27b, miR-16-1, mir-28, miR-31 and let-7g) bind to fibrillarin, a specific protein component of functional box C/D snoRNP complexes. The data suggest that a subset of small regulatory RNAs may have evolved from box C/D snoRNAs.
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