期刊
NUCLEIC ACIDS RESEARCH
卷 39, 期 -, 页码 D849-D855出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkq879
关键词
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资金
- European Commission [223592]
- National Institutes of Health, National Human Genome Research Institute [HG004074]
- MRC [MC_PC_U127527203, MC_U127527203] Funding Source: UKRI
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U01HG004074] Funding Source: NIH RePORTER
- Medical Research Council [MC_U127527203, MC_PC_U127527203] Funding Source: researchfish
The International Knockout Mouse Consortium (IKMC) aims to mutate all protein-coding genes in the mouse using a combination of gene targeting and gene trapping in mouse embryonic stem (ES) cells and to make the generated resources readily available to the research community. The IKMC database and web portal (www.knockoutmouse.org) serves as the central public web site for IKMC data and facilitates the coordination and prioritization of work within the consortium. Researchers can access up-to-date information on IKMC knockout vectors, ES cells and mice for specific genes, and follow links to the respective repositories from which corresponding IKMC products can be ordered. Researchers can also use the web site to nominate genes for targeting, or to indicate that targeting of a gene should receive high priority. The IKMC database provides data to, and features extensive interconnections with, other community databases.
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