期刊
NUCLEIC ACIDS RESEARCH
卷 39, 期 -, 页码 D1060-D1066出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkq1037
关键词
-
资金
- International Research Training Group on Genomics and Systems Biology of Molecular Networks [GRK1360]
- German Federal Ministry of Education and Research (MedSys)
- European Commission (SynSys)
- Deutsche Forschungsgemeinschaft [SFB 449]
The procedure of drug approval is time-consuming, costly and risky. Accidental findings regarding multi-specificity of approved drugs led to block-busters in new indication areas. Therefore, the interest in systematically elucidating new areas of application for known drugs is rising. Furthermore, the knowledge, understanding and prediction of so-called off-target effects allow a rational approach to the understanding of side-effects. With PROMISCUOUS we provide an exhaustive set of drugs (25 000), including withdrawn or experimental drugs, annotated with drug-protein and protein-protein relationships (21 500/104 000) compiled from public resources via text and data mining including manual curation. Measures of structural similarity for drugs as well as known side-effects can be easily connected to protein-protein interactions to establish and analyse networks responsible for multi-pharmacology. This network-based approach can provide a starting point for drug-repositioning. PROMISCUOUS is publicly available at http://bioinformatics.charite.de/promiscuous.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据