期刊
NUCLEIC ACIDS RESEARCH
卷 39, 期 -, 页码 D342-D346出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkq1072
关键词
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资金
- US National Science Foundation through its Engineering Research Center Program [EEC-0813570]
- Iowa State University
- Rice University
- University of California, Irvine
- University of New Mexico
- University of Virginia
- University of Wisconsin-Madison
The ThYme (Thioester-active enzYme; http://www.enzyme.cbirc.iastate.edu) database has been constructed to bring together amino acid sequences and 3D (tertiary) structures of all the enzymes constituting the fatty acid synthesis and polyketide synthesis cycles. These enzymes are active on thioester-containing substrates, specifically those that are parts of the acyl-CoA synthase, acyl-CoA carboxylase, acyl transferase, ketoacyl synthase, ketoacyl reductase, hydroxyacyl dehydratase, enoyl reductase and thioesterase enzyme groups. These groups have been classified into families, members of which are similar in sequences, tertiary structures and catalytic mechanisms, implying common protein ancestry. ThYme is continually updated as sequences and tertiary structures become available.
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