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Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing
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Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1
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Studies with the human cohesin establishment factor, ChlR1 - Association of ChlR1 with Ctf18-RFC and Fen1
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Long patch base excision repair in mammalian mitochondrial Genomes
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Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways
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Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria
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Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair
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Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease
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Fen1 mutations result in autoimmunity, chronic inflammation and cancers
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Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice
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MOLECULAR AND CELLULAR BIOLOGY (2007)
Concerted action of exonuclease and gap-dependent endonuclease activities of FEN-1 contributes to the resolution of triplet repeat sequences (CTG)n- and (GAA)n-derived secondary structures formed during maturation of Okazaki fragments
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Fen1 does not control somatic hypermutability of the (CTG)n•(CAG)n repeat in a knock-in mouse model for DM1
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Complex minisatellite rearrangements generated in the total or partial absence of Rad27/hFEN1 activity occur in a single generation and are Rad51 and Rad52 dependent
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Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score
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Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases
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DNA polymerase β and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair
Y Liu et al.
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The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors
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Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks
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The Fen1 extrahelical 3′-flap pocket is conserved from archaea to human and regulates DNA substrate specificity
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WRN helicase and FEN-1 form a complex upon replication arrest and together process branch-migrating DNA structures associated with the replication fork
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Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair
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The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1
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Human DNA ligase I completely encircles and partially unwinds nicked DNA
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Interaction interface of human flap endonuclease-1 with its DNA substrates
JZ Qiu et al.
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Y Liu et al.
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The identification and optimization of 2,4-diketobutyric acids as flap endonuclease 1 inhibitors
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Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in α-segment processing during Okazaki fragment maturation
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Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer
M Sato et al.
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Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage
E Larsen et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation
G Henneke et al.
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The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants
O Imamura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation
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EMBO JOURNAL (2003)
Flap endonuclease 1:: a novel tumour suppresser protein
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Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG
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The acetylatable lysines of human Fen1 are important for endo- and exonuclease activities
E Friedrich-Heineken et al.
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A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining
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Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
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Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex
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The 'flap' endonuclease gene FEN1 is excluded as a candidate gene implicated in the CAG repeat expansion underlying Huntington disease
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