期刊
NUCLEIC ACIDS RESEARCH
卷 38, 期 3, 页码 1009-1021出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkp1029
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资金
- National Institutes of Health [1S10RR16659, CA122952]
- The China Scholarship Council
- National Institutes of Health
- NATIONAL CANCER INSTITUTE [R01CA122952] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR016659] Funding Source: NIH RePORTER
Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K+ solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
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