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Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
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The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
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The structural determinants of checkpoint activation
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Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells
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DNA nucleotide excision repair-dependent signaling to checkpoint activation
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The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1
Yoshitami Hashimoto et al.
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Direct requirement for Xmus 101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling
S Yan et al.
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Rapid activation of ATR by ionizing radiation requires ATM and Mre11
JS Myers et al.
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TopBP1 activates the ATR-ATRIP complex
A Kumagai et al.
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Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences
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Identification and functional analysis of TopBP1 and its homologs
V Garcia et al.
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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
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ANNUAL REVIEW OF BIOCHEMISTRY (2004)
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
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Preferential binding of ATR protein to UV-damaged DNA
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Cell cycle checkpoint signaling through the ATM and ATR kinases
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