期刊
NUCLEIC ACIDS RESEARCH
卷 36, 期 6, 页码 2060-2072出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkn049
关键词
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资金
- NCRR NIH HHS [C06 RR017417, C06 RR17417-01] Funding Source: Medline
- NIAID NIH HHS [AI055599, R56 AI055599, R01 AI055599, R01 AI055599-05] Funding Source: Medline
Antigen receptor genes are assembled by a site-specific DNA rearrangement process called V(D)J recombination. This process proceeds through two distinct phases: a cleavage phase in which the RAG1 and RAG2 proteins introduce DNA double-strand breaks at antigen receptor gene segments, and a joining phase in which the resulting DNA breaks are processed and repaired via the non-homologous end-joining (NHEJ) repair pathway. Genetic and biochemical evidence suggest that the RAG proteins play an active role in guiding the repair of DNA breaks introduced during V(D)J recombination to the NHEJ pathway. However, evidence for specific association between the RAG proteins and any of the factors involved in NHEJ remains elusive. Here we present evidence that two components of the NHEJ pathway, Ku70 and Ku80, interact with full-length RAG1, providing a biochemical link between the two phases of V(D)J recombination.
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