期刊
SURVEY OF OPHTHALMOLOGY
卷 60, 期 3, 页码 242-249出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.survophthal.2015.01.003
关键词
conventional dendritic cells; myeloid dendritic cells; plasmacytoid dendritic cells; noninfectious uveitis; experimental autoimmune uveitis
资金
- Intramural Research Program of the National Institute of Eye, NIH
- Academy of Medical Sciences (AMS) [AMS-SGCL5-Denniston] Funding Source: researchfish
Dendritic cells (DCs) are a heterogeneous population. Murine DCs consist of conventional DCs (cDCs) and plasmacytoid DCs (pDCs). In humans, the analogous populations are myeloid DCs (mDCs) and pDCs. Though distinct in phenotypes and functions, studies have shown that these DC subsets may interact or crosstalk during immune responses. For example, cDCs may facilitate pDC maturation, and pDCs may enhance antigen presentation of cDCs in certain pathogenic conditions or even take on a cDC phenotype themselves. The role of DCs in noninfectious uveitis has been studied primarily in the experimental autoimmune uveitis mouse model and to a more limited extent in patients. Recent evidence shows that the number, phenotype, and function of DC subsets are altered in this disease. We provide an overview of selected recent developments of pDCs and cDCs/mDCs, with special attention to their interaction and the dual roles of DC subsets in noninfectious uveitis. Published by Elsevier Inc.
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