Simple and effective method for producing [C-11]phosgene using an environmental CCl4 gas detection tube

Introduction: Carbon-11-labeled phosgene is an important labeling precursor for PET molecular probes. Despite the usefulness of [C-11] phosgene, some difficulties, especially in the formation of [C-11]phosgene process from [C-11]CCl4, hamper its use. The present article shows a simple preparation method For [C-11]phosgene. Method: [C-11]CCl4 was obtained using the conventional method by passing a mixture of [C-11]CH4 and Cl-2 through a heated quartz tube. The [C-11]CCl4 was transformed to [C-11]phosgene simply by passing through a pretreatment tube of a Kitagawa gas detection system for the working-environmental CCl4 concentration measurement at room temperature with a flow rate of 50 ml/min. Result: This tube successfully transformed [C-11]CCl4 to [C-11]phosgene at room temperature. [C-11]Phosgene was obtained at nearly 80% radiochemical yield (EOB) in a short synthesis time with high reproducibility. Conclusion: A high yield and reliable [C-11]phosgene production method using a gas detector tube system for working-environmental CCl4 concentration measurement was developed. (C) 2010 Elsevier Inc. All rights reserved.