期刊
NONLINEAR ANALYSIS-REAL WORLD APPLICATIONS
卷 13, 期 4, 页码 1913-1940出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.nonrwa.2011.12.019
关键词
Biological complexity; Tumors; Population dynamics; Mathematical biology; Nonlinear ODE
资金
- FIRB [RBID08PP3J]
- INDAM-GNFM [43]
- University of Catania under PRA
This paper deals with the mathematical modeling of the mammary carcinoma-immune system competition elicited by an external stimulus represented by three different protocols of the triplex vaccine [C. De Giovanni, et al., Immunoprevention of HER-2/neu transgenic mammary carcinoma through an interleukin 12-engineered allogeneic cell vaccine, Cancer Research 64 (2004) 4001-4009]. The presented model is composed of nonlinear ordinary differential equations based on parameters and cell populations. A qualitative analysis of the asymptotic behavior of the model and numerical simulations are able to depict preclinical experiments on transgenic mice in tune with the SimTriplex model [F. Pappalardo, F. Castiglione, P.L. Lollini, S. Motta, Modelling and simulation of cancer immunoprevention vaccine, Bioinformatics 21 (2005) 2891-2897]. The results are of great interest both in the applied and theoretical sciences. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据