期刊
NMR IN BIOMEDICINE
卷 27, 期 10, 页码 1239-1247出版社
WILEY
DOI: 10.1002/nbm.3184
关键词
chemical exchange saturation transfer (CEST); amide proton transfer (APT); asymmetric magnetization transfer ratio; head and neck tumor; parotid gland
资金
- Hong Kong Research Grants Council (RGC) [SEG_CUHK02]
- Hong Kong RGC [CUHK418811]
- National Natural Science Foundation of China (NSFC) [81201076]
- USA National Institutes of Health (NIH) [R01EB009731, R01CA166171]
The aim of this study was to explore the feasibility and repeatability of amide proton transfer-weighted (APTw) MRI for the head and neck on clinical MRI scanners. Six healthy volunteers and four patients with head and neck tumors underwent APTw MRI scanning at 3T. The APTw signal was quantified by the asymmetric magnetization transfer ratio (MTRasym) at 3.5ppm. Z spectra of normal tissues in the head and neck (masseter muscle, parotid glands, submandibular glands and thyroid glands) were analyzed in healthy volunteers. Inter-scan repeatability of APTw MRI was evaluated in six healthy volunteers. Z spectra of patients with head and neck tumors were produced and APTw signals in these tumors were analyzed. APTw MRI scanning was successful for all 10 subjects. The parotid glands showed the highest APTw signal (similar to 7.6% average), whereas the APTw signals in other tissues were relatively moderate. The repeatability of APTw signals from the masseter muscle, parotid gland, submandibular gland and thyroid gland of healthy volunteers was established. Four head and neck tumors showed positive mean APTw ranging from 1.2% to 3.2%, distinguishable from surrounding normal tissues. APTw MRI was feasible for use in the head and neck regions at 3T. The preliminary results on patients with head and neck tumors indicated the potential of APTw MRI for clinical applications. Copyright (c) 2014 John Wiley & Sons, Ltd.
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