期刊
NMR IN BIOMEDICINE
卷 26, 期 10, 页码 1278-1284出版社
WILEY
DOI: 10.1002/nbm.2949
关键词
chemical exchange saturation transfer (CEST); glutamate; subcortical brain structures; amygdala; magnetic resonance spectroscopy (MRS)
资金
- National Center for Research Resources
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [P41 EB015893, R21-DA032256, R01-MH060722, P50-MH064045, T32 MH019112]
In vivo measurement of glutamate (Glu) in brain subcortex can elucidate the role these structures play in cognition and neuropsychiatric disorders. However, accurate quantification of Glu in subcortical regions is challenging. Recently, a novel MRI method based on the Glu chemical exchange saturation transfer (GluCEST) effect has been developed for detecting brain Glu in millimolar concentrations. Here, we use GluCEST to map Glu distributions in subcortical structures of the human brain (e. g. amygdala, hippocampus). Overall, GluCEST was similar to 40% higher in gray matter than in white matter. Within the subcortical gray matters, amygdala showed the highest GluCEST contrast. Utilizing MR spectroscopic data, in vivo GluCEST detection sensitivity (similar to 0.8% mM(-1)) in subcortical gray matter was evaluated and was consistent with the previously reported values. In general, the GluCEST map approximates the Glu receptor distribution reported in previous positron emission tomography (PET) studies. These findings suggest that high-resolution GluCEST MRI of subcortical brain structures may prove to be a useful tool in diagnosis of brain disorders or treatment responses. Copyright (C) 2013 John Wiley & Sons, Ltd.
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