期刊
NMR IN BIOMEDICINE
卷 24, 期 10, 页码 1326-1336出版社
WILEY
DOI: 10.1002/nbm.1694
关键词
MEMRI; Dehydration Induced Anorexia; hypothalamus; 14; 1T
资金
- Centre d'Imagerie Biomedicale (CIBM) of the University of Lausanne (UNIL)
- Ecole Polytechnique Federale de Lausanne (EPFL)
- University Hospital of Geneva (HUG)
- Centre Hospitalier Universitaire Vaudois (CHUV)
- Leenards Foundation
- Jeantet Foundation
In this study, hypothalamic activation was performed by dehydration-induced anorexia (DIA) and overnight food suppression (OFS) in female rats. The assessment of the hypothalamic response to these challenges by manganese-enhanced MRI showed increased neuronal activity in the paraventricular nuclei (PVN) and lateral hypothalamus (LH), both known to be areas involved in the regulation of food intake. The effects of DIA and OFS were compared by generating T-score maps. Increased neuronal activation was detected in the PVN and LH of DIA rats relative to OFS rats. In addition, the neurochemical profile of the PVN and LH were measured by 1H MRS at 14.1T. Significant increases in metabolite levels were measured in DIA and OFS relative to control rats. Statistically significant increases in -aminobutyric acid were found in DIA (p=0.0007) and OFS (p<0.001) relative to control rats. Lactate increased significantly in DIA (p=0.03), but not in OFS, rats. This work shows that manganese-enhanced MRI coupled to 1H MRS at high field is a promising noninvasive method for the investigation of the neural pathways and mechanisms involved in the control of food intake, in the autonomic and endocrine control of energy metabolism and in the regulation of body weight. Copyright (C) 2011 John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据