期刊
NMR IN BIOMEDICINE
卷 24, 期 2, 页码 114-129出版社
WILEY
DOI: 10.1002/nbm.1570
关键词
perfluorocarbon; MR contrast agent; lung ventilation; oxygen measurement; molecular imaging; cellular imaging
资金
- National Institute of Health [RO1 EB007829, RO1 EB007825, RO1 DA026299, 2RO1 NS045062, Roadmap R21 EB005252]
- NMSS [RG3630]
- Maryland Nanotechnology Research and Industry Fund (MCINN) [SAF2008-05412]
- [MSCRF-07-06-29-0]
Shortly after the introduction of H-1 MRI, fluorinated molecules were tested as MR-detectable tracers or contrast agents. Many fluorinated compounds, which are nontoxic and chemically inert, are now being used in a broad range of biomedical applications, including anesthetics, chemotherapeutic agents, and molecules with high oxygen solubility for respiration and blood substitution. These compounds can be monitored by fluorine (F-19) MRI and/or MRS, providing a noninvasive means to interrogate associated functions in biological systems. As a result of the lack of endogenous fluorine in living organisms, F-19 MRI of 'hotspots' of targeted fluorinated contrast agents has recently opened up new research avenues in molecular and cellular imaging. This includes the specific targeting and imaging of cellular surface epitopes, as well as MRI cell tracking of endogenous macrophages, injected immune cells and stem cell transplants. Copyright (C) 2010 John Wiley & Sons, Ltd.
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