期刊
NMR IN BIOMEDICINE
卷 24, 期 1, 页码 25-34出版社
WILEY
DOI: 10.1002/nbm.1552
关键词
functional MRI; blood oxygenation level dependent; 7 T; extravascular; intravascular; R-2*
资金
- Dunhill Medical Trust, The Netherlands Organisation for Scientific Research [N01-EB004130, NIH-P41RR015241]
- MRC [G0700399] Funding Source: UKRI
- Medical Research Council [G0700399] Funding Source: researchfish
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR015241] Funding Source: NIH RePORTER
The characterisation of the extravascular (EV) contribution to the blood oxygenation level-dependent (BOLD) effect is important for understanding the spatial specificity of BOLD contrast and for modelling approaches that aim to extract quantitative metabolic parameters from the BOLD signal. Using bipolar crusher gradients, total (b = 0 s/mm(2)) and predominantly EV (b = 100 s/mm(2)) gradient echo BOLD Delta R-2* and signal changes (Delta S/S) in response to visual stimulation (flashing checkerboard; f = 8 Hz) were investigated sequentially (within < 3 h) at 1.5, 3.0 and 7.0 Tin the same subgroup of healthy volunteers (n = 7) and at identical spatial resolutions (3.5 X 3.5 X 3.5 mm(3)). Total Delta R-2* (z-score analysis) values were -0.61 +/- 0.10 s(-1) (1.5 T), -0.74 +/- 0.05 s(-1) (3.0 T) and -1.37 +/- 0.12 s(-1) (7.0 T), whereas EV Delta R-2* values were -0.28 +/- 0.07 s(-1) (1.5 T), -0.52 +/- 0.07 s(-1) (3.0 T) and -1.25 +/- 0.11 s(-1) (7.0 T). Although EV Delta R-2* increased linearly with field, as expected, it was found that EV Delta S/S increased less than linearly with field in a manner that varied with TE choice. Furthermore, unlike Delta R-2*, total and EV Delta S/S did not converge at 7.0 T. These trends were similar whether a z-score analysis or occipital lobe-based region-of-interest approach was used for voxel selection. These findings suggest that calibrated BOLD approaches may benefit from an EV Delta R-2* measurement as opposed to a Delta S/S measurement at a single TE. Copyright (C) 2010 John Wiley & Sons, Ltd.
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