期刊
NMR IN BIOMEDICINE
卷 23, 期 7, 页码 698-710出版社
WILEY
DOI: 10.1002/nbm.1518
关键词
diffusion; non-Gaussian; brain; MRI; kurtosis; DKI; DTI
资金
- National Institutes of Health [1R01AG027852, 1R01EB007656]
- Litwin Foundation for Alzheimer's Research
- Werner Dannheisser Trust
- Institute for the Study of Aging
Quantification of non-Gaussianity for water diffusion in brain by means of diffusional kurtosis imaging (DKI) is reviewed. Diffusional non-Gaussianity is a consequence of tissue structure that creates diffusion barriers and compartments. The degree of non-Gaussianity is conveniently quantified by the diffusional kurtosis and derivative metrics, such as the mean, axial, and radial kurtoses. DKI is a diffusion-weighted MRI technique that allows the diffusional kurtosis to be estimated with clinical scanners using standard diffusion-weighted pulse sequences and relatively modest acquisition times. DKI is an extension of the widely used diffusion tensor imaging method, but requires the use of at least 3 b-values and 15 diffusion directions. This review discusses the underlying theory of DKI as well as practical considerations related to data acquisition and post-processing. It is argued that the diffusional kurtosis is sensitive to diffusional heterogeneity and suggested that DKI may be useful for investigating ischemic stroke and neuropathologies, such as Alzheimer's disease and schizophrenia. Copyright (C) 2010 John Wiley & Sons, Ltd.
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