期刊
NMR IN BIOMEDICINE
卷 22, 期 1, 页码 54-64出版社
WILEY
DOI: 10.1002/nbm.1301
关键词
breast cancer; spectroscopy; fine-needle aspiration biopsy; in vivo; pattern recognition; diagnosis; prognosis
资金
- NSW Cancer Council
- NSW Health
- NSW Department of Regional Development
- Australian NH&MRC Clinical Centres of Excellence Program
- Australian Federal Government Innovation Flagship Program
- Australian Research Council
Information for determining whether a primary breast lesion is invasive and its receptor status and grade can be obtained before surgery by performing proton MRS on a fine-needle aspiration biopsy (FNAB) specimen and analyzing the MRS information by a pattern recognition method. Two-dimensional MRS, on either specimens or cells, allows the unambiguous assignment of most resonances. When correlated with the spectral regions selected by the pattern recognition method, there are strong indications for the biochemical markers responsible for prognostic information of invasive capacity and metastatic spread. Spectral assignments and biological correlations can be made using cell models. In vivo MRS can distinguish invasive from benign lesions. This pathological distinction can be made from the presence of resonances at discrete frequencies. To achieve this level of spectral resolution and signal-to-noise ratio, there are stringent requirements when acquiring and processing the data. The challenge now is to implement two-dimensional MRS in vivo. Until this is realized, the combination of in vivo MR, for diagnosis and spatial location, and MRS, for image-guided biopsy to provide information on tumor spread, promises to provide a higher level of preoperative diagnosis than previously achieved. Copyright (C) 2008 John Wiley & Sons, Ltd.
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