期刊
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
卷 35, 期 -, 页码 175-185出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.niox.2013.09.004
关键词
Nitric oxide; Endothelial cell; Smooth muscle cell; Blood vessel injury; Intimal hyperplasia; Transplant vasculopathy
Nitric oxide (NO) is an intra- and inter-signaling molecule that regulates vessel dilatation, neuronal transmission, cardiac contraction, immunomodulation, and stem cell differentiation and proliferation. NO plays an important protective role in the cardiovascular system. NO inhibits smooth muscle cells proliferation and migration; enhances proliferation and migration of endothelial cell. and inhibits apoptosis; suppresses platelet aggregation; and prevents platelet, leukocyte and monocyte adhesion to endothelium. NO exerts an inhibitory effect on the development of intimal hyperplasia in mechanically or immunologically injured vessel. New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease. (C) 2013 Elsevier Inc. All rights reserved.
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