期刊
NEW JOURNAL OF CHEMISTRY
卷 38, 期 11, 页码 5226-5239出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nj00654b
关键词
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资金
- CNRS
- UDS
- French Ministry of Research
- Region Alsace
- University of Mons, Belgium
- European Union (European Regional Development Fund - ERDF) in the framework of the program Nano@matrix INTERREG IV Upper Rhine Valley. Transcending borders with every project
- ANR
We report herein the synthesis of biocompatible small-sized phosphonated monomers and dendrons used as functional coatings of metal oxide nanoparticles, more specifically superparamagnetic iron oxides (SPIOs) for magnetic resonance imaging (MRI) and therapy through hyperthermia. The molecules were engineered to modulate their size, their hydrophilic and/or biocompatible character (poly(amido) amine versus oligoethyleneglycol), the number of anchoring phosphonate groups (monophosphonate versus phosphonic tweezers) and the number of peripheral functional groups for further grafting of dyes or specific vectors. Such a library of hydrophilic phosphonic acids opens new possibilities for the investigation of dendronized nanohybrids as theranostics.
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