4.6 Article

Efficient synthesis of small-sized phosphonated dendrons: potential organic coatings of iron oxide nanoparticles

期刊

NEW JOURNAL OF CHEMISTRY
卷 38, 期 11, 页码 5226-5239

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nj00654b

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资金

  1. CNRS
  2. UDS
  3. French Ministry of Research
  4. Region Alsace
  5. University of Mons, Belgium
  6. European Union (European Regional Development Fund - ERDF) in the framework of the program Nano@matrix INTERREG IV Upper Rhine Valley. Transcending borders with every project
  7. ANR

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We report herein the synthesis of biocompatible small-sized phosphonated monomers and dendrons used as functional coatings of metal oxide nanoparticles, more specifically superparamagnetic iron oxides (SPIOs) for magnetic resonance imaging (MRI) and therapy through hyperthermia. The molecules were engineered to modulate their size, their hydrophilic and/or biocompatible character (poly(amido) amine versus oligoethyleneglycol), the number of anchoring phosphonate groups (monophosphonate versus phosphonic tweezers) and the number of peripheral functional groups for further grafting of dyes or specific vectors. Such a library of hydrophilic phosphonic acids opens new possibilities for the investigation of dendronized nanohybrids as theranostics.

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