期刊
NEW JOURNAL OF CHEMISTRY
卷 36, 期 11, 页码 2242-2252出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2nj40186j
关键词
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资金
- The University of the Witwatersrand
- Molecular Sciences Institute
- Friedel Sellshop Grant
The supramolecular reagent isonicotinamide (isonico) was used to co-crystallize with three liquid carboxylic acids, cyclopropanecarboxylic acid (C(3)A), cyclobutanecarboxylic acid (C(4)A) and cyclopentanecarboxylic acid (C(5)A), and a solid carboxylic acid, cyclohexanecarboxylic acid (C(6)A). A total of six co-crystal structures resulted, which are an illustration of the co-crystal space observed in the ever-expanding research on co-crystallization of multiple molecular components. Co-crystal 1, (C(3)A).(isonico), has a crystal structure with one of the highest reported Z' values. 12 acid and 12 isonico molecules combine in the asymmetric unit to give a Z' = 12, all forming 1-D ribbons. Co-crystals 2a and 2b, both having a formula of (C(4)A)(2).(isonico), having, respectively, a Z' of 1 and 2, illustrate both stoichiometric variation as well as polymorphism, resulting in different packing architectures. Co-crystals (C(5)A).(isonico) 3 and (C(6)A).(isonico) 4 have isostructural structures at low temperature, and both show phase transitions above room temperature. For (C(6)A).(isonico), we determined the structure of both the low temperature phase, 4a, as well as a high temperature phase, 4b, by single crystal X-ray diffraction, and monitored the transition of 3 by variable temperature powder X-ray diffraction. In all of the compounds reported here, synthesized from two components that are not necessarily solids at ambient conditions and which we have called co-crystals, the primary hydrogen bonded interaction is the carboxylic acid .... pyridine hydrogen bond.
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