期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 588, 期 -, 页码 15-24出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2015.10.016
关键词
Hydropersulfide; Thiols; Redox regulation; Nucleophilicity; Electrophilicity
资金
- National Institutes of Health [HL106598]
- National Science Foundation [CHE-1148641, CHE-1126482]
- ACS-PRF grant [52801-ND4]
- Grants-in-Aid for Scientific Research [26111008, 26670207, 15H06509] Funding Source: KAKEN
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1126482] Funding Source: National Science Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1148641] Funding Source: National Science Foundation
Recent reports indicate the ubiquitous prevalence of hydropersulfides (RSSH) in mammalian systems. The biological utility of these and related species is currently a matter of significant speculation. The function, lifetime and fate of hydropersulfides will be assuredly based on their chemical properties and reactivity. Thus, to serve as the basis for further mechanistic studies regarding hydropersulfide biology, some of the basic chemical properties/reactivity of hydropersulfides was studied. The nucleophilicity, electrophilicity and redox properties of hydropersulfides were examined under biological conditions. These studies indicate that hydropersulfides can be nucleophilic or electrophilic, depending on the pH (i.e. the protonation state) and can act as good one- and two-electron reductants. These diverse chemical properties in a single species make hydropersulfides chemically distinct from other, well-known sulfur containing biological species, giving them unique and potentially important biological function. (C) 2015 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据