Novel trimethyl lock based enzyme switch for the self-assembly and disassembly of gold nanoparticles

A novel trimethyl lock based dual enzyme-responsive gold nanoparticles (AuNPs) conjugate was developed to control the self-assembly and disassembly of AuNPs in one population of nanoparticles, which can be easily monitored by naked eye, simple spectrophotometer and surface enhanced Raman scattering (SERS) measurements.