期刊
STEROIDS
卷 104, 期 -, 页码 270-275出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2015.10.013
关键词
Trillium govanianum; Trilliaceae; Spirostane glycosides; Govanoside A; Antifungal
资金
- Higher Education Commission (HEC) of Pakistan
A new spirostane steroidal saponin, govanoside A (1) along with three known compounds borassoside E (2) pennogenin (3) and diosgenin (4) were isolated from rhizomes of Trillium govanianum. Their structures were elucidated through 1D, 2D-NMR spectroscopic data analysis and acid hydrolysis. Compound (2) in genus Trillium and all compounds (1-4) in T. govanianum are reported herein for the first time. Furthermore, compounds 1 & 2 exhibited good to moderate activities against Aspergillus niger ATCC 16888, Aspergillus flavus ATCC 9643, Candida albicans ATCC 18804, and Candida glabrata ATCC 90030. This is a significant finding keeping in view the limited antifungal drugs for aspergillosis and candidiasis. (C) 2015 Elsevier Inc. All rights reserved.
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