期刊
NEW ENGLAND JOURNAL OF MEDICINE
卷 358, 期 25, 页码 2698-2703出版社
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMoa0800251
关键词
-
资金
- NCI NIH HHS [R01 CA104711, R21 CA128283-02, CA12823, CA1047113, R01 CA104711-05, R21 CA128283] Funding Source: Medline
- NCRR NIH HHS [M01 RR000037-47, M01 RR000037] Funding Source: Medline
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据