期刊
STEM CELLS
卷 33, 期 4, 页码 1036-1041出版社
WILEY-BLACKWELL
DOI: 10.1002/stem.1959
关键词
Glia; Induced pluripotent stem cells; Neural differentiation; Neural stem cell; Stem cell transplantation; Spinal cord injury
资金
- Miguel Servet contract of Instituto de Salud Carlos III of Spanish Ministry of Science and Innovation
- Fund for Health of Spain [PI10-01683]
- Junta de Andalucia [PI-0113-2010]
- Wings for Life Foundation
- Czech National Foundation GA CR [P304/12/G069]
- MEYS of the CR under the NPU I programme from the European Regional Development Fund [LO1309]
Spinal cord injury (SCI) usually results in long lasting locomotor and sensory neuron degeneration below the injury. Astrocytes normally play a decisive role in mechanical and metabolic support of neurons, but in the spinal cord they cause injury, exerting well-known detrimental effects that contribute to glial scar formation and inhibition of axon outgrowth. Cell transplantation is considered a promising approach for replacing damaged cells and promoting neuroprotective and neuroregenerative repair, but the effects of the grafted cells on local tissue and the regenerative properties of endogenous neural stem cells in the injured spinal cord are largely unknown. During the last 2 decades cumulative evidence from diverse animal models has indicated that reactive astrocytes in synergy with transplanted cells could be beneficial for injury in multiple ways, including neuroprotection and axonal growth. In this review, we specifically focus on the dual opposing roles of reactive astrocytes in SCI and how they contribute to the creation of a permissive environment when combined with transplanted cells as the influential components for a local regenerative niche. Modulation of reactive astrocyte function might represent an extremely attractive new therapy to enhance the functional outcomes in patients. Stem Cells2015;33:1036-1041
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