期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 576, 期 -, 页码 49-60出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2015.03.024
关键词
Drug-DNA binding; Intercalation; Groove binding; Electrostatic interactions
资金
- CSIR, New Delhi [09/112(0470)/2011-EMR1]
- UGC
- DBT, New Delhi [BT/PR8032/BID/7/443/2013]
Drug-DNA interactions have been extensively studied in the recent past. Various techniques have been employed to decipher these interactions. DNA is a major target for a wide range of drugs that may specifically or non-specifically interact with DNA and affect its functions. Interaction between small molecules and DNA are of two types, covalent interactions and non-covalent interactions. Three major modes of non-covalent interactions are electrostatic interactions, groove binding and intercalative binding. This review primarily focuses on discussing various techniques used to study non-covalent interactions that occur between drugs and DNA. Additionally, we report several techniques that may be employed to analyse the binding mode of a drug with DNA. These techniques provide data that are reliable and simple to interpret. (C) 2015 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据