期刊
NEUROTOXICOLOGY AND TERATOLOGY
卷 34, 期 6, 页码 545-553出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ntt.2012.08.006
关键词
Zebrafish; Toxicity screening; Developmental neurotoxicity; Model
资金
- Dutch Ministry of Health, Welfare and Sport
- Dutch Ministry of Social Affairs and Employment
- Netherlands' Ministry of Defence under R&T Program V936 'Military Toxicology'
The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms of toxicants. The use of zebrafish in toxicity research can ultimately lead to the refinement or reduction of animal use. (C) 2012 Elsevier Inc. All rights reserved.
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