期刊
NEUROTOXICOLOGY
卷 38, 期 -, 页码 131-135出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.neuro.2013.07.002
关键词
Brain; Epidemiology; Essential tremor; Harmane; Pathology; Toxicant
资金
- NIEHS NIH HHS [R01 ES008146] Funding Source: Medline
- NINDS NIH HHS [R01 NS039422] Funding Source: Medline
Background: Harmane (1-methyl-9H-pyrido[3,4-beta]indole), a potent neurotoxin that has tremor-producing properties in animal models, is present in many foods; although we have demonstrated a difference in tissue harmane concentrations in ET cases vs. controls, all work to date has involved blood samples. Objectives: We quantified harmane concentrations in human cerebellum, a brain region of particular pathogenic interest in essential tremor (ET), comparing ET to control brains. Methods: Cerebellar cortex was snap frozen and stored at -80 degrees C in aliquots for biochemical analyses. Harmane concentration was assessed using high performance liquid chromatography. Results: Geometric mean brain harmane concentrations (adjusted for postmortem interval [PMI] and freezer time) were higher in ET cases than controls: 1.0824 (95% confidence interval = 0.9405-1.2457) vs. 0.8037 (0.6967-0.9272), p = 0.004. Geometric mean of brain harmane concentrations (adjusting for PMI and freezer time) was highest in ET cases who reported other relatives with tremor (1.2005 [0.8712-1.6541]), intermediate in ET cases without family history (1.0312 ([0.8879-1.1976]), and both were significantly higher than controls (p = 0.02). Conclusions: This study provides additional evidence of a possible etiological importance of this toxin in some cases of the human disease ET. (C) 2013 Elsevier Inc. All rights reserved.
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