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Rory Johnson et al.
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Jodi L. McBride et al.
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Elizabeth A. Thomas et al.
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M. DiFiglia et al.
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Penelope Hogarth et al.
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Edward C. Stack et al.
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Jim P. Dompierre et al.
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Ana M. M. Oliveira et al.
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Y Machida et al.
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R Wu et al.
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SQ Harper et al.
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CA Ross et al.
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S Dasgupta et al.
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