期刊
NEUROSURGERY CLINICS OF NORTH AMERICA
卷 25, 期 3, 页码 497-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.nec.2014.04.008
关键词
Cerebral vasospasm; Subarachnoid hemorrhage; Neurologic deficits; Delayed ischemic neurologic injury
Cerebral vasospasm causes delayed ischemic neurologic deficits after aneurysmal subarachnoid hemorrhage. This is a well-established clinical entity with significant associated morbidity and mortality. The underlying patholphysiology is highly complex and poorly understood. Large-vessel vasospasm, autoregulatory dysfunction, inflammation, genetic predispositions, microcirculatory failure, and spreading cortical depolarization are aspects of delayed neurologic deterioration that have been described in the literature. This article presents a perspective on cerebral vasospasm, as guided by the literature to date, specifically examining the mechanism, diagnosis, and treatment of cerebral vasospasm.
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