期刊
NEUROSIGNALS
卷 21, 期 3-4, 页码 240-258出版社
KARGER
DOI: 10.1159/000339091
关键词
Chemokines; Cancer; Brain; Neuropathology
资金
- National Natural Science Foundation of China [30901536]
- Natural Science Foundation of Shandong [ZR2010HQ026]
- Promotive research fund for excellent young and middle-aged scientists of Shandong Province [BS2011SW015]
- Independent Innovation Foundation of Shandong University [2010TS103]
The SDF-1 alpha/CXCR4 signaling maintains central nervous system homeostasis through the interaction with the neurotransmitter and neuropeptide systems, the neuroendocrine systems. Recently, the SDF-1 alpha/CXCR4 signaling has been reported to present nonrandom distribution in brain development and glioma progression, which exerts differential regulations on the assembly, differentiation, and function of neural precursors, neurons, glial cells, as well as glioma cells. In the present review, we highlight current knowledge about multiple molecular signaling pathways associated with the SDF-1 alpha/CXCR4 signaling in glioma. Not only is the expression of CXCR4 a key determinant of glioma progression, but SDF-1 alpha is essential for site-specific invasive or metastatic processes. SDF-1 alpha is the switch of the SDF-1 alpha/CXCR4 signaling from the endocrine loop to the autocrine and/or local paracrine loop in glioma progression and brain development. Studies of SDF-1 alpha/CXCR4 signaling in the field of brain development may provide valuable tactics for glioma treatment. Copyright (c) 2012 S. Karger AG, Basel
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