期刊
NEUROSCIENTIST
卷 18, 期 4, 页码 360-372出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858411422754
关键词
seizure; coupling; functional network; structural network; rhythms
资金
- Scientific Interface from the Burroughs Wellcome Fund
- National Institute of Neurological Disorders and Stroke [R01 NS062092]
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [1042134] Funding Source: National Science Foundation
The brain is naturally considered as a network of interacting elements which, when functioning properly, produces an enormous range of dynamic, adaptable behavior. However, when elements of this network fail, pathological changes ensue, including epilepsy, one of the most common brain disorders. This review examines some aspects of cortical network organization that distinguish epileptic cortex from normal brain as well as the dynamics of network activity before and during seizures, focusing primarily on focal seizures. The review is organized around four phases of the seizure: the interictal period, onset, propagation, and termination. For each phase, the authors discuss the most common rhythmic characteristics of macroscopic brain voltage activity and outline the observed functional network features. Although the characteristics of functional networks that support the epileptic seizure remain an area of active research, the prevailing trends point to a complex set of network dynamics between, before, and during seizures.
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