期刊
NEUROSCIENTIST
卷 16, 期 2, 页码 156-170出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858409355830
关键词
traumatic brain injury; spinal cord injury; angiogenesis; oxidative stress; blood-brain barrier; glial scar
资金
- NIH [NS050159, NS039278]
- Alvera Kan Endowed Chair
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS050159, R01NS039278] Funding Source: NIH RePORTER
Matrix metalloproteinases (MMPs) are involved in a wide range of proteolytic events in fetal development and normal tissue remodeling as well as wound healing and inflammation. In the CNS, they have been implicated in a variety of neurodegenerative diseases ranging from multiple sclerosis to Alzheimer disease and are integral to stroke-related cell damage. Although studies implicate increased activity of MMPs in pathogenesis in the CNS, there is also a growing literature to support their participation in events that support recovery processes. Here the authors provide a brief overview of MMPs and their regulation, address their complex roles following traumatic injuries to the adult and developing CNS, and consider their time- and context-dependent signatures that influence both injury and reparative processes.
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