期刊
NEUROSCIENTIST
卷 16, 期 3, 页码 244-252出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858409349903
关键词
nerve growth factor; brain-derived neurotrophic factor; p75 neurotrophin receptor; Trk; hippocampus
资金
- NIH [NS045556, MH071624]
- New Jersey Commission on Brain Injury Research [08-3211]
Neurons respond to numerous factors in their environment that influence their survival and function during development and in the mature brain, Among these factors, the neurotrophins have been shown to support neuronal survival and function, acting primarily through the Trk family of receptor tyrosine kinases. However, recent studies have established that the uncleaved neurotrophin precursors, the proneurotrophins, can be secreted and induce apoptosis via the p75 neurotrophin receptor, suggesting that the balance of secreted mature and proneurotrophins has a critical impact on neuronal survival or death. Epileptic seizures elicit increases in both proneurotrophin secretion and p75(NTR) expression, shifting the balance of these factors toward signaling cell death. This review will discuss the evidence that this ligand-receptor system plays an important role in neuronal loss following seizures.
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