期刊
NEUROSCIENCE RESEARCH
卷 74, 期 3-4, 页码 200-209出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2012.10.005
关键词
WGA-HRP; CTB; Retrograde tracers; Hippocampus; Topography
资金
- Ministry of Education, Science, Sports and Culture of Japan [20591032, 24591305]
- Global COE program, Multidisciplinary Education and Research Center for Regenerative Medicine (MERCREM)
- Ministry of Education, Culture, Sports Science, and Technology (MEXT)
- Grants-in-Aid for Scientific Research [24591305, 20591032] Funding Source: KAKEN
The distribution pattern of the cells that give rise to perforant path projections, including direct entorhino-CA1 and entorhino-subicular projections, was investigated in layer III of the medial and lateral entorhinal areas in the rat using retrograde labeling with horseradish peroxidase conjugated to wheat germ agglutinin and cholera toxin B subunit. Using two-dimensional unfolded maps of the entire hippocampal and parahippocampal fields, we found that cells projecting to a certain septotemporal level of CA1 and the subiculum were distributed in a band-like zone extending across the medial and lateral entorhinal areas. The transverse axis of these zones was disposed parallel to the rhinal fissure and their longitudinal axis was perpendicular to the boundary between the medial and lateral entorhinal areas. Projections to the septal CA1 originated from the zone near the rhinal fissure, whereas those to the temporal CA1 originated from the zone far from the rhinal fissure. Each zone in both the medial and lateral entorhinal areas involved many neurons projecting to a wide proximodistal range of CA1 and the subiculum. These results suggest that the entorhino-CA1 and entorhino-subicular perforant path projections are generally organized in a band-like zonal fashion with a gradient, rather than a point-to-point topographic arrangement. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据