期刊
NEUROSCIENCE RESEARCH
卷 71, 期 4, 页码 421-426出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2011.08.012
关键词
Extracellular matrix; Axon outgrowth; Dendrite outgrowth; Dendrite sprouting; Laminin E8 fragment; Integrin
资金
- Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [22122006] Funding Source: KAKEN
Laminins play an important role in neuronal development. However, the effects of each laminin isoform on neurite morphology remain unclear. Here, we examined the effects of particular laminin (LN) isoforms on hippocampal neuron morphology. We found that LN-511 remarkably promoted elongation of both axons and dendrites, but reduced the number of dendrites. LN-511 E8 fragment, which includes the integrin-binding region, promoted axon and dendrite outgrowth and increased the dendrite number, although its effect on axon and dendrite elongation was smaller than that of full-length LN-511. These results suggest that LN-511 regulates axon and dendrite development by integrin-dependent and -independent mechanisms. (C) 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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