期刊
NEUROSCIENCE RESEARCH
卷 64, 期 4, 页码 362-371出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2009.04.009
关键词
Dneurexin; PDZ domain; Synaptic vesicle; Endocytosis; Neurotransmission
资金
- National Natural Science Foundation [30571045]
- National Basic Research Program (973 Program) [2005CB522501]
- MOE [03083]
- Foundation for Excellent Doctoral Dissertation of Southeast University [YBJJ0520]
Neurexins are neuron-specific cell surface molecules thought to localize to presynaptic membranes. Recent genetic studies using Drosophila melanogaster have implicated an essential role for a single Drosophila neurexin (dnrx) in the proper architecture, development and function of synapses in vivo. However, the precise mechanisms underlying these actions are not fully understood. To elucidate the molecular mechanism of Neurexin in vivo, we employed dnrx and caki mutant flies, combined with various methods, and analyzed the animals' locomotion, synaptic vesicle cycling and neurotransmission of neuromuscular junctions. We found that Dneurexin (DNRX) is important for locomotion through a genetic interaction with the scaffold protein, CAKI/CMG, the Drosophila homolog of vertebrate CASK. Similar to its mammalian counterparts, DNRX is essential for synaptic vesicle cycling, which plays critical roles in neurotransmission at neuromuscular junctions (NMJ). However, this interaction appears not to be required for the synaptic targeting of DNRX, but may instead be needed for proper synaptic function, possibly by regulating the synaptic vesicle cycling process. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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