期刊
NEUROSCIENCE LETTERS
卷 566, 期 -, 页码 21-26出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2014.02.038
关键词
Childhood absence epilepsy; High-frequency oscillations; Morlet continuous wavelet transform; Dynamic magnetic source imaging; Magnetoencephalography
资金
- Key Project of Medical Science and Technology Development Foundation, Nanjing Department of Health [ZKX11002]
This study aimed to use ictal high-frequency oscillations (HF05) ranging from 80 Hz to 500 Hz to locate seizure onset zones in childhood absence epilepsy (CAE) using non-invasive magnetoencephalography (MEG). Ten drug-na ve children with CAE were studied using a 275-channel MEG system. MEG data were digitized at a sampling rate of 6000 Hz. HFO spectral power in real-time spectrograms was assessed using Monet continuous wavelet transform. Magnetic sources were volumetrically localized through dynamic magnetic source imaging with a slide window. HFOs were identified in all patients. The total time of fast ripples (250-500 Hz) was greater than that of ripples (80-250 Hz) during absence seizures. The rate of fast ripples was associated with seizure frequency. HFO duration was significantly longer when co-occurring with spikes than when occurring independently, and the maximum frequency of HFOs co-occurring with spikes was higher than that of HFOs occurring independently. HFOs were predominantly localized in the medial prefrontal cortex (MPFC), whereas spikes were widespread to a variety of regions during the absence seizures. Compared with spikes, HFOs appeared to be more focal. The findings indicate that HFOs in the MPFC have a primary function in initializing epileptic activity in CAE. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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