期刊
NEUROSCIENCE LETTERS
卷 558, 期 -, 页码 97-102出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.10.037
关键词
NeuN; Rbfox3; HIV-associated neurocognitive disorders; Splicing; Neurodegeneration; Gene expression
资金
- Manhattan HIV Brain Bank [U01MH083501, R24MH59724]
- Texas NeuroAIDS Research Center [U01MH083507, R24 NS45491]
- National Neurological AIDS Bank [5U01MH083500, NS 38841]
- California NeuroAIDS Tissue Network [U01MH083506, R24MH59745]
- Statistics and Data Coordinating Center [U01MH083545, N01MH32002]
- US National Institutes of Mental Health [R21 MH095646]
The anti-NeuN antibody has been widely used for over 15 years to unambiguously identify post-mitotic neurons in the central nervous system of a wide variety of vertebrates including mice, rats and humans. In contrast to its widely reported nuclear localization, we found significantly higher NeuN reactivity in the cytoplasm of neurons in brain sections from HIV-infected individuals with cognitive impairment compared to controls. The protein target of anti-NeuN antisera was recently identified as the neuron-specific RNA splicing factor, Rbfox3, but its significance in diseases affecting the brain has not been previously reported. RNA splicing occurs in the nucleus hence, the altered localization of RbFox3 to the cytoplasm may lead to the downregulation of neuronal gene expression. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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