期刊
NEUROSCIENCE LETTERS
卷 550, 期 -, 页码 55-59出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.06.061
关键词
NTRK2; Alzheimer's disease; Neurotrophin; Single nucleotide polymorphism; Promoter
资金
- National Natural Science Foundation of China [81270423, 30973144, 81000549]
- Natural Science Foundation Project of CQCSTC [CSTC2010BA5004]
Alzheimer's disease (AD) is characterized by the degeneration of basal forebrain cholinergic neurons, whose survival and function are affected by neurotrophins and their receptors. The impaired signaling pathway of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) is considered to play an important role in AD pathogenesis. To explore the association of polymorphisms within the NTRK2 gene (encoding TrkB) and sporadic AD (sAD), a case-control study was conducted in a Chinese Han cohort including 216 sAD patients and 244 control participants. Five single nucleotide polymorphisms (SNPs), with four of them within the promoter region and one in intron, were selected and genotyped with a polymerase chain reaction-ligase detection reaction (PCR-LDR) method. No association was revealed between these SNPs or the haplotypes containing four promoter SNPs and the risk of sAD. The results of this study indicate that polymorphisms in the selected regions of the NTRK2 gene are unlikely to confer the susceptibility of sAD in the Chinese Han population. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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