期刊
NEUROSCIENCE LETTERS
卷 541, 期 -, 页码 258-262出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.02.049
关键词
Dopamine beta hydroxylase; Polymorphism; Heroin addiction
资金
- National Basic Research Program of China [2009CB522008]
- Nature Science Foundation of China [81071077, U1132602]
- Ningbo Social Development Research Projects [2012C50032]
- K.C. Wong Magna Fund in Ningbo University [2007A22008]
- Ningbo Science and Technology Foundation, Zhejiang Province, China [2007A22008]
By balancing the ratios of dopamine and norepinephrine, dopamine beta hydroxylase (DBH) plays an important role in brain reward circuit that is involved with behavioral effects of heroin addiction. DBH - 1021C/T (rs1611115) is a functional variant with strong correlation with plasma DBH activity and several nerval and psychic disorders. In the present study, we have collected 333 male cases with heroin addiction and 200 male healthy controls to explore the role of 1021C/T in heroin addiction. There is no evidence of association between 1021C/T and heroin addiction on both genotype and allele levels (P>0.05). In the injection subgroup of cases, - 1021TT carriers have longer heroin addiction time (P<0.001) and higher dosage of self-administered heroin (P=0.045) than carriers with - 1021CC or - 1021CT, suggesting that patients with TT genotype are likely to have more progressive style of heroin users with injection route. In conclusion, our results support - 1021TT genotype may be implicated with a more progressive nature of heroin addiction, although DBH 1021C/T is unlikely to be involved in the risk of heroin addiction. Crown Copyright (C) 2013 Published by Elsevier Ireland Ltd. All rights reserved.
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