期刊
NEUROSCIENCE LETTERS
卷 548, 期 -, 页码 249-254出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.05.038
关键词
IGF-2; IGFBP2; Osteoglycin; Neurite outgrowth; SH-SY5Y
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2011-0003358, 2011-0025844]
A previous study using a mouse model of depression showed that chronic immobilization stress (CIS) reduces levels of insulin-like growth factor (IGF)-2, IGF binding protein 2 (IGFBP2), osteoglycin, and fibromodulin in the amygdala. Here, using human neuroblastoma cells, we tested whether these four proteins cooperatively modulate neuronal plasticity. We found that IGF-2 and IGFBP2 synergistically increased neurite outgrowth via enhanced early signaling through the IGF type 1 receptor. Furthermore, we found that osteoglycin, a small leucine-rich proteoglycan, significantly increased IGF-2/IGFPB2-induced neurite outgrowth, but fibromodulin had no effect. We also found that central amygdala neurons of CIS-induced depressive mouse showed a decreased total dendritic length. These findings suggest that CIS-responsive proteins modulate neuronal morphology during chronic stress. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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