期刊
NEUROSCIENCE LETTERS
卷 541, 期 -, 页码 275-280出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.02.005
关键词
TNF-alpha; Anxiety; Inflammation; Pain
资金
- National Natural Science Foundation of China [30672384]
Tumor necrosis factor alpha (TNF-alpha) is known for its role in inflammation and pain, which are strongly associated with mood disorders such as anxiety and depression. The amygdala is a forebrain structure that modulates anxiety. However, little is known about the role of TNF-alpha in the development of anxiety in animals with chronic pain. In the present study, we examined TNF-alpha expression in the basolateral amygdala (BLA) following injection of complete Freund's adjuvant (CFA) into the hind paw of mice to induce inflammation. We also determined the effects of TNF-alpha expression on the development of anxiety in these mice. TNF-alpha expression was increased in the BLA during the chronic phase of CFA-induced peripheral inflammation. The local infusion of TNF-alpha-neutralizing antibody infliximab in the BLA reversed anxiety-like behaviors in mice with persistent inflammatory pain. In vitro slice recordings revealed that TNF-alpha significantly enhanced AMPA-receptor-mediated glutamatergic excitatory synaptic transmission and inhibited GABA(A)-receptor-mediated inhibitory synaptic transmission in the BLA. Our findings, therefore, provide strong evidence that TNF-alpha contributes to the development of anxiety in mice with persistent inflammatory pain. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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