期刊
NEUROSCIENCE LETTERS
卷 512, 期 2, 页码 94-98出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.01.064
关键词
Emotions; IAPS; Amygdala; fMRI
Purpose: The purpose of this study was to investigate the brain circuitry involved in the processing of both positive and negative emotions in normal healthy subjects. Method: we have recruited 15 healthy volunteers (9 males and 6 females, age range 30-60). In this block-design fMRI study, we compared the blood oxygen level dependant (BOLD) signal change as response to pleasant and unpleasant IAPS pictures, each compared to a neutral condition. Results: Pleasant pictures versus neutral condition contrast demonstrated significant activation (p(FDRcorrected) <0.05) in bilateral pre-frontal cortex (PFC), anterior and posterior cingulate gyri and temporal lobe. Unpleasant pictures relative to neutral condition exhibit significant activation (P-FDRcorrected <0.05) in amygdala, hippocampus, parahippocampal gyri, temporal lobe, visual cortex, fusiform gyri, PFC and anterior cingulate gyrus. Conclusion: Amygdala is mainly involved in the processing of negative emotions. Although an overlap in regions involved in the processing of pleasant and unpleasant LAPS pictures exists, the neural network for each is unique. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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