期刊
NEUROSCIENCE LETTERS
卷 526, 期 2, 页码 79-84出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.08.028
关键词
Anxiety Brain-derived neurotrophic factor (BDNF); Glial cell line-derived neurotrophic factor (GDNF); Knockout mouse; Lipopolysaccharides-induced tumor necrosis factor-alpha factor (LITAF); Shati
资金
- Comprehensive Research grant on Aging and Health from the Ministry of Health, Labor and Welfare of Japan
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- JSPS (Kakenhi)
- Smoking Research Foundation Grant for Biomedical Research
- Academic Frontier Project grant for Private Universities from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- Funding Program for Next Generation World-Leading Researchers (NEXT Program)
We previously identified a novel molecule Shati/Nat8l from the nucleus accumbens of mice. However, the physiological roles of the SHATI protein are not clear. To investigate the effect of SHATI on the central nervous system and behavior, we studied knockout mice of this protein. We carried out various behavior tests using Shari-knockout mice. Shati-knockout mice did not differ from wild type mice in learning and memory. In the open field test, Shari-knockout mice did not differ from wild-type mice in time of stay in the outer, middle and center areas. On the other hand, Shari-knockout mice showed increases in rearing and grooming time in the open field test, and exploration time of novel objects. These results suggested that knockout of the Shari gene may increase exploration in specific circumstances. Interestingly, the Shati-knockout mice avoided social interaction with unfamiliar mice out of their home cage, although there was no difference in social interaction in their home cage compared with wild type mice. Lack of the Shari gene increased brain-derived neurotrophic factor (BDNF) mRNA in the prefrontal cortex and hippocampus, and decreased glial cell line-derived neurotrophic factor (GDNF) mRNA in the striatum and hippocampus, and lipopolysaccharides-induced TNF-alpha factor (LITAF) mRNA in the striatum. Since these factors play important roles in behavior, alteration of expression of these factors may be related to the induction of exploration and reduction of social interaction in Shari-knockout mice. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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