期刊
NEUROSCIENCE LETTERS
卷 509, 期 1, 页码 64-68出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.12.053
关键词
Retinoic acid vitamins; Paraventricular hypothalamic nucleus; Perifornical region; Immunohistochemistry
资金
- GEMAC S.A. Laboratories (Saint Jean d'Illac, France)
- IDRPHT (Talence, France)
In order to increase our knowledge about the distribution of vitamins in the mammalian brain, we have developed a highly specific antiserum directed against retinoic acid with good affinity (10(-8)M), as evaluated by ELISA tests. In the rat brain, no immunoreactive fibers containing retinoic acid were detected. Cell bodies containing retinoic acid were only found in the hypothalamus. This work reports the first visualization and the morphological characteristics of cell bodies containing retinoic acid in the mammalian paraventricular hypothalamic nucleus and in the dorsal perifornical region, using an indirect immunoperoxidase technique. The restricted distribution of retinoic acid in the rat brain suggests that this vitamin could be involved in very specific physiological mechanisms. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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